San Francisco 49ers RB Christian McCaffrey bursts through the defense for a 41-yard run against the Chicago Bears.

McCaffrey’s cut left Jaylon Johnson grasping at air, and instead of bringing down San Francisco’s shifty running back, he ...

Saquon Barkley will aim to run over the San Francisco 49ers defense on Sunday, hoping to help his Philadelphia Eagles advance ...

The key weapon for the 49ers against the Eagles is clear. San Francisco's game plan on Sunday must revolve around one player.

San Francisco 49ers running back Christian McCaffrey follows two perfect blocks en route to a 5-yard touchdown run.

EAST RUTHERFORD, N.J. (AP) — Christian McCaffrey and Brian Robinson Jr. kept getting the ball and carving through the New York Giants' defense. San Francisco 49ers coach Kyle Shanahan wondered if he ...

Christian McCaffrey stiff-arms Giants cornerback Andru Phillips on his way to 173 total yards and two touchdowns in Sunday’s win at MetLife Stadium. EAST RUTHERFORD, N.J. — Christian McCaffrey and ...

SANTA CLARA, Calif. -- After another physical, grind-it-out win against the Los Angeles Rams last week, San Francisco 49ers running back Christian McCaffrey stood at a lectern with a big grin on his ...