Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by the aggregation of alpha-synuclein in the brain. Now, scientists have developed a radioligand that facilitates the ...

Researchers have designed a peptide that prevents the deadly misfolding of alpha-synuclein, the protein behind Parkinson’s and some dementias. In lab and animal tests, it stabilized the protein and ...

In a recent study published in the Proceedings of the National Academy of Sciences, researchers assessed the capability of two small molecules of disintegrating alpha-synuclein fibrils. Parkinson's ...

Phosphorylation of α-synuclein at serine 129 has long been used as a marker of synucleinopathy—p-S129syn accumulates in Lewy bodies, after all. But does this modification have a physiological function ...

In the brain, alpha-synuclein is known for forming clumps called Lewy bodies, which damage brain cells and lead to diseases ...

The sunbird Syn (TM) assay accurately classified Parkinson's disease-positive blood samples with 81% accuracy through the direct detection of EV-bound aggregated alpha-synuclein proteins -- -- With no ...